Research Areas：

My research direction mainly focuses on the prevention and treatment of geriatric diseases and nursing, as well as the combination of medical care and nursing. In line with the national policy, aim at the elderly population to improve the quality of life of the elderly.

1. Shandong University Qilu Hospital, Horizontal: Clinical Research on Radiofrequency Ablation of Hemorrhoids, 6010124098, May 23, 2024 - April 30, 2026, Project Leader (First), Project Funding: RMB 40,000, Research in Progress

2. Shandong University School of Nursing and Rehabilitation, Horizontal: Development and Translational Research of a Sangkudzu-Removing Herbal Drink, 1330023003, June 1, 2023 - June 1, 2026, Project Leader (First), Project Funding: RMB 600,000, Research in Progress

3. Shandong University School of Nursing and Rehabilitation, Horizontal: Research on the Development and Translational Application of Phellinus Lindl. and Its Regeneration Clinical and Experimental Research on the Prevention and Treatment of Lung Cancer with a Prescription of a Prescription for Lung Cancer, 1330023002, April 17, 2023-April 17, 2026, Project Leader (First), Project Funding: 1.5 million RMB, Research in Progress

4. Shandong Provincial Society of Gerontology and Geriatrics, Horizontal: Designation of the Prevention and Intervention Guidelines for Disabled and Semi-Disabled Elderly People in Shandong Province, 1330022001, March 15, 2022-March 15, 2024, Project Leader (First), Project Funding: 94,000 RMB

5. Shandong Provincial Association for Science and Technology Research Project (Vertical), Academic Promotion of Integrated Medical and Nursing Care Guangji Demonstration Area Research, July 2018-December 2019, Project Leader (First), RMB 100,000

6. Shandong Provincial Natural Science Foundation Project (Vertical), Study on the Mechanism of Allicin in Improving Vascular Endothelial Cell Dysfunction in HHcy Mice, August 2017-June 2020, Project Leader (First), RMB 140,000

7. Shandong Association for Science and Technology Research Project (Vertical), Promotion of Traditional Chinese Medicine Paste Formula Technology and Development of Healthy Foods, May 2017-December 2019, Project Leader (First), RMB 315,0008)

8. Shandong University Research Project, Fuzheng Xiaoju Recipe Research on the clinical efficacy and mechanism of action of a drug for treating tumors, January 2014-December 2018, Project Leader (first project), RMB 300,000

9. Research project funded by the State Administration of Traditional Chinese Medicine, National Academic School - Qilu Internal Medicine Current Disease School Inheritance Studio, January 2013-January 2016, Sub-project Leader, Total funding: RMB 1 million, Sub-project funding: RMB 160,000

10. National Natural Science Foundation Project, Research on the relationship between diabetic brain function impairment and hypoxia and the molecular mechanism of the anti-hypoxia effect of the Qi-Yi Bushen Formula, January 2012-December 2015, Project Leader (first project), RMB 600,000

Selected Publications

1. Sheng Y, Wang C, Wang Y, Pan L, Zhang M, Liu D*, Gao, W*. An umbrella review of physical-activity therapy and cognitive behavioral therapy in reducing fear of falling among community-dwelling older adults: insights on intervention intensity and duration. Frontiers in public health, 2025,12, 1498451. doi:10.3389/fpubh.2024.1498451.

2. Zhang J, Li C, Li W, Shi Z., Liu Z, Zhou, J, Tang J, Ren Z, Qiao Y, Liu D*. Mechanism of luteolin against non-small-cell lung cancer: a study based on network pharmacology, molecular docking, molecular dynamics simulation, and in vitro experiments. Frontiers in oncology.2024 NOV;14. doi:10.3389/fonc.2024.1471109.

3. Li W, Liu Z, Song M, Shi Z, Zhang J, Zhou J, Liu Y, Qiao Y, Liu D*. Mechanism of Yi-Qi-Bu-Shen Recipe for the Treatment of Diabetic Nephropathy Complicated with Cognitive Dysfunction Based on Network Pharmacology and Experimental Validation. Diabetes, metabolic syndrome and obesity : targets and therapy.2024,17:3943-3963. doi:10.2147/DMSO.S481740.

4.Yan C, Wang C, Ding X, Sun L, Gao W, Liu D*. Profiles in neglect of older adult care workers in a long-term care facility: a latent profile analysis. Front Public Health. 2024;12:1320896. doi:10.3389/fpubh.2024.1320896

5. Chi H, Sun Y, Lin P, et al. Glucose Fluctuation Inhibits Nrf2 Signaling Pathway in Hippocampal Tissues and Exacerbates Cognitive Impairment in Streptozotocin-Induced Diabetic Rats. J Diabetes Res. 2024;2024:5584761. Published 2024Jan 19. doi:10.1155/2024/5584761

6. Li W, Liu Z, Song M, et al. Be Alert to Diabetes Nephropathy with Cognitive Dysfunction [Response to Letter]. Diabetes Metab Syndr Obes. 2024;17:4661-4662. Published 2024 Dec 6. doi:10.2147/DMSO.S508433

7. Sun LF, Lu Q, Gao W, Li XX, Cheng JQ, Liu DS*, Cao YJ. Study on the influence of patient safety culture on the pain and turnover intention of Chinese nurses in adverse nursing events. Nurs Open. 2023 Oct;10(10):6866-6874.

8. Song M, Huai B, Shi Z, Li W, Xi Y, Liu Z, Zhang J, Zhou J, Qiao Y, Liu D*. The efficacy and safety of Chinese herbal medicine in the treatment of painful diabetic neuropathy: A systematic review and meta-analysis. Front Pharmacol. 2023 Mar 6;14:1072991. doi: 10.3389/fphar.2023.1072991.

9. Huai B, Huai B, Su Z, Song M, Li C, Cao Y, Xin T, Liu D*. Systematic evaluation of combined herbal adjuvant therapy for proliferative diabetic retinopathy. Front Endocrinol (Lausanne). 2023 May 18;14:1157189. doi: 10.3389/fendo.2023.1157189.

10. Chi H, Song M, Zhang J, Zhou J, Liu D*. Relationship between acute glucose variability and cognitive decline in type 2 diabetes: A systematic review and meta-analysis. PLoS One. 2023 Sep 1;18(9):e0289782. doi: 10.1371/journal.pone.0289782.

11. Hou Y, Gao G, Ding W, et al. Transcriptome and Pathway Analysis Reveals that Adipose-derived Stem Cells Target Inflammatory Factors and Delay the Progression of Diabetic Liver Disease. Front Biosci (Landmark Ed). 2023;28(12):365. doi:10.31083/j.fbl2812365

12. Feng Q, Li G, Xia W, Dai G, Zhou J, Xu Y, Liu D* and Zhang G *. The anti-aging effects of Renshen Guben on thyrotoxicosis mice: Improving immunosenescence, hypoproteinemia, lipotoxicity, and intestinal flora[J]. Front Immunol.2022 Oct; 13:983501. doi: 10.3389/fimmu.2022.983501

13. Li CL, Liu B, Wang ZY, Xie F, Qiao W, Cheng J, Kuang JY, Wang Y, Zhang MX*, Liu DS*. Salvianolic acid B improves myocardial function indiabetic car diomyopathy by suppressing IGFBP3[J]. J Mol Cell Cardiol, 2020 Feb, 139: 98-112. doi: 10.1016/j.yjmcc.2020.01.009

Membership:

1. Chinese Geriatrics Society, Vice President

2. Chinese Geriatrics Society's Branch of Integrated Traditional Chinese and Western Medicine, President

3. Shandong Geriatrics Society, President

4. Traditional Chinese Medicine Branch and the Diabetes Branch of the Shandong Geriatrics Society, Chairperson

5. Shandong Provincial Committee of the China Peasants' and Workers' Democratic Party,Vice Chairman

6. Department of Integrated Traditional Chinese and Western Medicine, Shandong University, Director

7. Geriatrics Committee and Executive Director of the Diabetes Committee, World Federation of Chinese Medicine, Vice President

8. Chronic Disease Prevention and Management Committee, Chinese Society of Integrated Traditional Chinese and Western Medicine, Standing Committee Member

9. Chinese Medical Doctor Association's Branch of Integrated Traditional Chinese and Western Medicine, Standing Committee Member

Awards & Honors:

1. Shandong Province Outstanding Contribution Award for Traditional Chinese Medicine, Shandong Provincial Department of Human Resources and Social Security and Shandong Provincial Health Commission, 2020

2. Expert of Shandong Province Famous Traditional Chinese Medicine Inheritance Studio, Shandong Provincial Health Commission, 2019

3. National Clinical Key Talent Instructor, State Administration of Traditional Chinese Medicine, 2019

4. "Respect Life, Honor Doctors" Chinese Medicine Contribution Award, Shandong Provincial Health Commission and Dazhong Daily, 2019

5. Outstanding Elite of Traditional Chinese Medicine, Shandong Medical Doctors Association, 2017

6. Shandong Natural Science Academic Innovation Award, Shandong Provincial Science and Technology Association, first place, 2018

7. Establishment and Practice of the "One Plus Three" Training Model for Innovative Master's Degree Students in Integrated Traditional Chinese and Western Medicine, Shandong University Teaching Achievement Award, second place, first place, 2017

8. Study on the Mechanism of Allicin's Intervention for Hyperhomocysteinemia and Its Atherosclerotic Effects, Shandong Higher Education Science and Technology Award, third place, first place, 2016

9. Study on the Effects and Mechanisms of Qi-Invigorating and Kidney-Tonifying Traditional Chinese Medicine on Improving Brain Function in Diabetics, Shandong Provincial People's Government, Shandong Provincial Science and Technology Progress Award, second place, first place, 2014

10. Application Research on the Qi-Invigorating and Kidney-Tonifying Formula in Preventing and Treating Diabetic Brain Function Decline, Ministry of Education, China Higher Education Outstanding Achievement Award, second place, first place, 2014